Metabolism of the Z and E Isomers of W-Nitroso-TV-methyHZ-oxopropyOamine by Rat Hepatocytes1
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چکیده
The metabolism of Y-nilroso-A'-nictliyl\-(2-ovcipn>pyl)aminc was ex amined using freshly isolated hepatocytes from Fischer 344 rats. As determined by high performance liquid chromatography, it was found that the E isomer was preferentially metabolized when the parent mixture was used. When the two isomers were studied separately, the E isomer was efficiently metabolized in the hepatocytic system, whereas the Z isomer was not. The kinetics of disappearance of the Z isomer during metabolism was identical to that for the reequilibration of the Z isomer to the mixture of isomers in the absence of a metabolizing system.
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